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The (SIN (Substitute It Now!) List ) is a database developed by the International Chemical Secretariat (ChemSec) of chemicals the uses of which are likely to become legally restricted under EU REACH regulation. The list is being used by public interest groups as a campaign tool to advocate for increasing the pace of implementation of REACH and by commercial interests to identify substances for control in chemicals management programmes. 〔(SIN List 2.1 update: new information from REACH registrations extends the SIN List )〕 == History and development == The SIN List is composed of chemicals evaluated by the environmental NGO ChemSec as meeting EU criteria for being Substances of Very High Concern (SVHCs) under Article 57 of REACH, being either carcinogenic, mutagenic or reprotoxic (CMR), persistent, bioaccumulative and toxic (PBT), very persistent and very bioaccumulative (vPvB), or posing an equivalent environmental or health threat.,〔〔ChemSec, (2008). ''Methodology for selection of substances included in the REACH SIN * List 1.0 ( *Substitute It Now)'' ((PDF) )〕 The first SIN List, known as version 1.0, was published in 2008 and identified 267 chemicals as meeting the Article 57 criteria for being SVHCs. ChemSec’s assessment was independently validated by the Technical University of Denmark.〔Eriksson E. H-C Holten-Lützhøft & A Ledin, (2009) ''Second opinion on the hazards associated with the substances selected for the REACH SIN * List 1.0.'' Technical University of Denmark. Denmark. ((PDF) )〕 In 2009 a further 89 substances were added to the SIN List (Version 1.1),〔ChemSec (2009) ''(The SIN List updated with substances newly classified within the EU – now containing 356 substances )''〕 before in 2011 another 22 chemicals were added (Version 2.0)〔ChemSec (2011) ''22 New SIN Substances''((PDF) )〕 for fulfilling the REACH 57(f) criterion of equivalent concern as endocrine disrupting chemicals (EDCs). The 2011 EDC additions were made in consultation with TEDX, the US endocrine-disruption research NGO founded by Professor Theo Colborn, and coincided with EU plans over 2011-2012 to develop accepted criteria for identifying endocrine disrupting chemicals.〔European Commission DG Environment, (2011). ''4th Report on the implementation of the "Community Strategy for Endocrine Disrupters" a range of substances suspected of interfering with the hormone systems of humans and wildlife (COM (1999) 706)''. Brussels, Belgium. ((PDF) )〕 In October 2014 the list was updated once again, this time with 28 new chemicals. With this update, the SIN List was also divided into 31 groups, and a tool for sustainable substitution based on the SIN List – SINimilarity – was presented.〔ChemSec. SIN List updated and new tool, SINimilarity, launched () Retrieved 08/10/14〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SIN (Substitute It Now!) List」の詳細全文を読む スポンサード リンク
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